Diflubenzuron

Mechanism of action

The mechanism of action of diflubenzuron involves inhibiting the production of chitin which is used by an insect to build its exoskeleton. It triggers insect larvae to molt early without a properly formed exoskeleton, resulting in the death of the larvae.

Environmental toxicity

Diflubenzuron has been evaluated by the United States Environmental Protection Agency (EPA), and it is classified as non-carcinogenic. 4-Chloroaniline, a metabolite of diflubenzuron which has been classified as a carcinogen, is produced after diflubenzuron has been ingested. The small amount converted to 4-chloroaniline after ingestion is not sufficient to cause cancer.

Commercial uses

A commercial preparation containing diflubenzuron is sold under the trade name Adept and is used as an insect growth regulator designed to kill fungus gnat larvae in commercial greenhouses. It is applied to infected soil and will kill fungus gnat larvae for 30–60 days from a single application. Although it is targeted at fungus gnat larvae, care should be taken in applying it as it is highly toxic to most aquatic invertebrates. It has no toxic effects on adult insects, only insect larvae are affected. Diflubenzuron can cause serious foliar injury to plants in the spurge family and certain types of begonia, particularly poinsettias, hibiscus and reiger begonia and should not be applied to these plant varieties.

Diflubenzuron is used as a larvicide in the cattle farming industry. Sold under the name Vigilante, it is formulated as a bolus and is used to control fly populations.

References

References

1. [https://pmep.cce.cornell.edu/profiles/extoxnet/dienochlor-glyphosate/diflubenzuron-ext.html Diflubenzuron Pesticide Information Profile], Extension Toxicology Network
2. (2019). "Benzoylphenyl ureas as veterinary antiparasitics. An overview and outlook with emphasis on efficacy, usage and resistance". Parasite.
3. (2016). "Insecticide Recommendations for Soybeans - 2016". University of Kentucky: College of Agriculture, Food and Environment.
4. "Reregistration Eligibility Decision Diflubenzuron".
5. "ADEPT Insect Growth Regulator".
6. "Adept label".
7. Kydonieus, Agis F.. (2017-10-02). "Treatise on Controlled Drug Delivery: Fundamentals-optimization-applications". Routledge.