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Dexketoprofen

Chemical compound

Summary

Chemical compound

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Dexketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It is manufactured by Menarini, under the tradename Keral. It is available in the UK, as dexketoprofen trometamol, as a prescription-only drug and in Latin America as Enantyum, produced by Menarini. Also, in Italy and Spain it is available as an over-the-counter drug (OTC) under the trade name Enandol or Enantyum. In Hungary it is available from a pharmacy as Ketodex. In Turkey, it is an over the counter medicine under the name Arveles. In Latvia, Lithuania and Estonia it is available as an OTC under the tradename Dolmen. In Mexico it is available in tablet form as Stadium made by Menarini. It is the dextrorotatory stereoisomer of ketoprofen.

Chemistry

Dexketoprofen is the (S)-enantiomer of ketoprofen. Technically it is a chiral switch of (±)-ketoprofen. The switch was done for a faster onset of action, a better therapeutic value. Dexketoprofen consists of a propionic acid moiety connected to a benzophenone molecule by its second carbon.

Medical uses

Short-term treatment of mild to moderate pain, including dysmenorrhoea. It is also used for migraines and knee pain.

Side effects

It may cause dizziness, and patients should not, therefore, drive or operate heavy machinery or vehicles until they are familiar with how dexketoprofen affects them. Concomitant use of alcohol and other sedatives may potentiate this effect. In a small subset of individuals the dizziness may be intolerable and require transition to an alternative treatment.

Pharmacology

Dexketoprofen belongs to a class of medicines called NSAIDs. It works by blocking the action of a substance in the body called cyclo-oxygenase, which is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain. By blocking cyclo-oxygenase, dexketoprofen prevents the production of prostaglandins and therefore reduces inflammation and pain. Along with peripheral analgesic action, it possesses central analgesic action.

References

References

  1. (22 May 2014). "Medicinal products authorised in Estonia".
  2. (2007). "xPharm: The Comprehensive Pharmacology Reference". Elsevier Inc.
  3. (March 2000). "Chiral switches". Lancet.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

propionic-acids benzophenones enantiopure-drugs nonsteroidal-anti-inflammatory-drugs
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