Desmoplastic trichoepithelioma

Signs and symptoms

Desmoplastic trichoepithelioma manifests as a firm, soft, or white to yellowish annular nodule or papule on the cheeks or face with a central indentation.

Causes

Familial desmoplastic trichoepitheliomas have been reported suggesting a possible genetic link.

Diagnosis

Desmoplastic trichoepithelioma can be diagnosed based on clinical and morphological features. Desmoplastic trichoepithelioma may resemble other tumors such as conventional trichoepithelioma, microcystic adnexal carcinoma, morpheaform basal cell carcinoma, and syringoma both clinically and histopathologically.

Treatment

The preferred course of treatment is surgical excision. Nonetheless, Mohs microscopic surgery is the method of choice for lesions, particularly those on the face.

Epidemiology

Desmoplastic trichoepithelioma is more common in females. It has a bimodal age distribution and usually affects adults or small children. Desmoplastic trichoepithelioma accounts for less than 1% of all cutaneous tumors.

References

References

1. (2006). "Andrews' Diseases of the Skin: Clinical Dermatology". Saunders Elsevier.
2. (2020-08-12). "Desmoplastic Trichoepithelioma: Histopathologic and Immunohistochemical Criteria for Differentiation of a Rare Benign Hair Follicle Tumor From Other Cutaneous Adnexal Tumors". Springer Science and Business Media LLC.
3. (2019). "Inherited desmoplastic trichoepitheliomas". Clinical and Experimental Dermatology.
4. (2015-07-21). "Desmoplastic trichoepithelioma: A clinicopathological study of three cases and a review of the literature". Spandidos Publications.
5. (2016). "A Case of Multiple Desmoplastic Trichoepithelioma". Korean Dermatological Association and The Korean Society for Investigative Dermatology.