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Dermatopathic lymphadenopathy
| Field | Value |
|---|---|
| synonym | Dermatopathic lymphadenitis |
| image | Dermatopathic lymphadenopathy - intermed mag.jpg |
| caption | Micrograph showing dermatopathic lymphadenopathy with the characteristic paracortical histiocytosis and melanin-laden macrophages. H&E stain. |
| specialty | Dermatology |
In pathology, dermatopathic lymphadenopathy, is lymph node pathology due to skin disease.
Cause
Also known as lipomelanotic reticulosis or Pautrier-Woringer disease, represents a rare form of benign lymphatic hyperplasia associated with most exfoliative or eczematoid inflammatory erythrodermas, including pemphigus, psoriasis, eczema, neurodermatitis, and atrophia senilis.
Diagnosis
Dermatopathic lymphadenopathy is diagnosed by a lymph node biopsy. It has a characteristic pattern of histomorphology and immunohistochemical staining:
- Paracortical histiocytosis
- Melanin-laden macrophages
- Eosinophils
- Plasma cells (medulla of lymph node)
Differential diagnosis
- Cutaneous T cell lymphoma
- Hodgkin's lymphoma
- Melanoma
Treatment
The treatment is based on the underlying cause.
References
References
- (2007). "Dermatopathic lymphadenopathy in a patient with adult onset Still's disease.". Clin Exp Rheumatol.
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