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DEFB105A

Protein-coding gene in humans

Beta-defensin 105 is a protein that is encoded by the DEFB105A gene in humans.

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: Alpha defensins, Beta defensins and Theta defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy.

References

(Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A.
(May 2003). "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol.
"Entrez Gene: DEFB105A defensin, beta 105A".

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