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Cytidine deaminase

Protein-coding gene in the species Homo sapiens

Summary

Protein-coding gene in the species Homo sapiens

Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene.

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. Most cytidine deaminases act on RNA, and the few that act on DNA require ssDNA.

A related activation-induced (cytidine) deaminase (AID) regulates antibody diversification, especially the process of somatic hypermutation.

Interactive pathway map

References

References

  1. (January 1993). "Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation". Biochemical and Biophysical Research Communications.
  2. (December 1998). "Isolation and characterization of the gene coding for human cytidine deaminase". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.
  3. "Entrez Gene: CDA cytidine deaminase".
  4. (May 2016). "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage". Nature.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-3.5.4
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