From Surf Wiki (app.surf) — the open knowledge base

Cyclin-dependent kinase regulatory subunit family

Field	Value
Symbol	CKS
Name	CKS
image	PDB 1dks EBI.jpg
caption	ckshs1: human cyclin dependent kinase subunit, type 1 in complex with phosphate
Pfam	PF01111
InterPro	IPR000789
PROSITE	PDOC00728
SCOP	1cks

In molecular biology, the cyclin-dependent kinase regulatory subunit family is a family of proteins consisting of the regulatory subunits of cyclin-dependent protein kinases.

In eukaryotes, cyclin-dependent protein kinases interact with cyclins to regulate cell cycle progression, and are required for the G1 and G2 stages of cell division. The proteins bind to a regulatory subunit, cyclin-dependent kinase regulatory subunit (CKS), which is essential for their function. This regulatory subunit is a small protein of 79 to 150 residues. In yeast (gene CKS1) and in fission yeast (gene suc1) a single isoform is known, while mammals have two highly related isoforms. The regulatory subunits exist as hexamers, formed by the symmetrical assembly of 3 interlocked homodimers, creating an unusual 12-stranded beta-barrel structure. Through the barrel centre runs a 12A diameter tunnel, lined by 6 exposed helix pairs. Six kinase units can be modelled to bind the hexameric structure, which may thus act as a hub for cyclin-dependent protein kinase multimerisation.

This family includes the CKS1B and CKS2 genes in mammals.

References

(November 1987). "p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase". EMBO J..
(October 1993). "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control". Science.
(May 1993). "The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae". Genes Dev..

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

cell-cycle-regulators protein-domains

Want to explore this topic further?

Ask Mako anything about Cyclin-dependent kinase regulatory subunit family — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report