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Cyclamide

Chemical structure of aerucyclamide A, a prototypical cyclamide

Cyclamides are a class of oligopeptides produced by cyanobacteria algae strains such as Microcystis aeruginosa. Some of them can be toxic.

Cyclamides are cyclopeptides with either six or eight amino acids, some of which are modified from their natural proteinogenic form. They are typically characterized by thiazole and oxazole rings which are thought to be cysteine and threonine derivatives, respectively.

References

(29 October 2018). "Cyclamides – a wealth of different bioactivities". NaToxAq, University of Copenhagen.
Ramsy Agha. (2013). "Limited Stability of Microcystins in Oligopeptide Compositions of Microcystis aeruginosa (Cyanobacteria): Implications in the Definition of Chemotypes". Toxins.
Cyril Portmann. (2008). "Aerucyclamides A and B: Isolation and Synthesis of Toxic Ribosomal Heterocyclic Peptides from the Cyanobacterium Microcystis aeruginosa PCC 7806". J. Nat. Prod..

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peptides cyanotoxins

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