Surf Wiki
Save to docs
general/dermal-and-subcutaneous-growths

From Surf Wiki (app.surf) — the open knowledge base

Cutaneous myxoma

FieldValue
synonymsSuperficial angiomyxoma
imageCutaneousMyxoma.jpg
captionCutaneous myxoma
specialty

A cutaneous myxoma, or superficial angiomyxoma, consists of a multilobulated myxoid mass containing stellate or spindled fibroblasts with pools of mucin forming cleft-like spaces. There is often a proliferation of blood vessels and an inflammatory infiltrate. Staining is positive for vimentin, negative for cytokeratin and desmin, and variable for CD34, Factor VIIIa, SMA, MSA and S-100.

Clinically, it may present as solitary or multiple flesh-colored nodules on the face, trunk, or extremities. It may occur as part of the Carney complex, and is sometimes the first sign. Local recurrence is common. Cutaneous myxoma is diagnosed based on histopathological features. The differential diagnosis for cutaneous myxoma include alopecia areata, verrucous hamartoma, cyst, fibroma, glioma, hemangioma, lipoma, scar, and nevus sebaceous. Treatment involves complete surgical excision.

Signs and symptoms

Cutaneous myxoma appears as a little, slowly expanding dermal or subcutaneous lump that typically affects adults' heads and necks. Alopecic lesions have been reported, characterized by hair tufts overlaying the lesion or even hypertrichosis. Although usually painless, some people have reported experiencing discomfort or tenderness. A pedunculated lesion was reported.

Causes

Cutaneous myxoma may occur in isolation or in association with syndromes such as nevi, atrial myxoma, myxoid neurofibromas, and ephelides (NAME) syndrome, Carney complex, and lentigines, atrial myxoma, mucocutaneous myxomas, and blue nevi (LAMB) syndrome.

Diagnosis

A thin arborizing vascular network, a large myxoid stroma, mild to moderate cellularity with spindled to stellate cells with little or mild atypia, and the lack of nuclear pleomorphism or mitotic activity are among the histologic markers that are consistently present in cutaneous myxoma.

Alopecia areata, verrucous hamartoma, cyst, fibroma, glioma, hemangioma, lipoma, scar, and nevus sebaceous are only a few of the many conditions included in the extensive clinical differential diagnosis.

Treatment

The main treatment for cutaneous myxoma is complete surgical excision.

References

References

  1. Satter EK. (October 2009). "Solitary superficial angiomyxoma: an infrequent but distinct soft tissue tumor". J. Cutan. Pathol..
  2. (2005). "Andrews' Diseases of the Skin: Clinical Dermatology". Saunders.
  3. Folpe, Andrew L.. (2009). "Diagnostic Surgical Pathology of the Head and Neck". Elsevier.
  4. (2009). "A meningioma of the scalp that might have developed from a rudimentary meningocele". Oxford University Press (OUP).
  5. (1995). "Primary Cutaneous Meningioma on the Scalp: Report of Two Siblings". Wiley.
  6. Peñas, Pablo F.. (1995-06-01). "Cutaneous Heterotopic Meningeal Nodules". American Medical Association (AMA).
  7. (1974). "Cutaneous meningiomas--a clinicopathologic study". Cancer.
  8. (1998). "Cutaneous meningioma of the scalp: a case report and review of literature". Elsevier BV.
  9. (1993). "Cutaneous meningioma: histochemical, immunohistochemical and ultrastructural investigation". Wiley.
  10. (2022). "A clinicopathologic analysis of 54 cases of cutaneous myxoma". Elsevier BV.
  11. (2012-02-01). "Cutaneous Meningioma". Archives of Pathology and Laboratory Medicine.
  12. (2007). "Extracranial meningioma and pregnancy: a rare diagnosis". Elsevier BV.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

dermal-and-subcutaneous-growths
Want to explore this topic further?

Ask Mako anything about Cutaneous myxoma — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report