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Crustacean neurohormone family

FieldValue
SymbolCrust_neurohorm
NameCrust_neurohorm
imagePDB 1j0t EBI.jpg
captionSolution structure of moult-inhibiting hormone from the kuruma prawn
PfamPF01147
InterProIPR001166
PROSITEPDOC00963
SCOP1j0t
OPM family75
OPM protein1j0t

In molecular biology, the crustacean neurohormone family of proteins is a family of neuropeptides expressed by arthropods. The family includes the following types of neurohormones:

  • Crustacean hyperglycaemic hormone (CHH). CHH is primarily involved in blood sugar regulation, but also plays a role in the control of moulting and reproduction.
  • Moult-inhibiting hormone (MIH). MIH inhibits Y-organs where moulting hormone (ecdysteroid) is secreted. A moulting cycle is initiated when MIH secretion diminishes or stops.
  • Gonad-inhibiting hormone (GIH), also known as vitellogenesis-inhibiting hormone (VIH) because of its role in inhibiting vitellogenesis in female animals.
  • Mandibular organ-inhibiting hormone (MOIH). MOIH represses the synthesis of methyl farnesoate, the precursor of insect juvenile hormone III in the mandibular organ.
  • Ion transport peptide (ITP) from locust. ITP stimulates salt and water reabsorption and inhibits acid secretion in the ileum of the locust.
  • Caenorhabditis elegans uncharacterised protein ZC168.2.

These neurohormones are peptides of 70 to 80 amino acid residues which are processed from larger precursors. They contain six conserved cysteines that are involved in disulfide bonds.

References

References

  1. (December 1995). "Molecular biology of neurohormone precursors in the eyestalk of Crustacea". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology.
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protein-families peptide-hormones
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