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Cruentaren

Group of chemical compounds

Cruentaren

Group of chemical compounds

Chemical structure of cruentaren A

Cruentarens are a group of macrolides secreted by the myxobacteria Byssovorax cruenta. There are two isomers (cruentaren A and B) have been isolated. They each have a molecular formula of C33H51NO8 and molecular weight 589 g/mol. Cruentaren A strongly inhibits the growth of yeasts and filamentous fungi, and inhibits the proliferation of different cancer cell lines in vitro, including a multidrug-resistant KB line. Cruentaren B shows only marginal cytotoxicity and no antifungal activity.

References

References

  1. Kunze, Brigitte. (2006). "Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (Myxobacteria) with inhibitory effect on mitochondrial ATPase activity : Fermentation and biological properties". Journal of Antibiotics.
  2. (2006). "Isolation and Structure Elucidation of Cruentarens A and B — Novel Members of the Benzolactone Class of ATPase Inhibitors from the Myxobacterium ''Byssovorax'' cruenta". European Journal of Organic Chemistry.
  3. (2007). "Cruentaren A, a highly cytotoxic benzolactone from ''Myxobacteriais'' a novel selective inhibitor of mitochondrial F1-ATPases". FEBS Letters.
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macrolides antifungals twelve-membered-rings tetrols carboxamides methoxy-compounds
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