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CPHPC

CPHPC ((R)-1-{6-[(R)-2-carboxypyrrolidin-1-yl]-6-oxohexanoyl}pyrrolidine-2-carboxylic acid) is a proline-derived small molecule able to strip amyloid P (AP) from deposits by reducing levels of circulating serum amyloid P (SAP). The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of CPHPC for amyloidosis.

CPHPC has also been patented for possible treatment of Alzheimer's disease.

Mechanism

The symmetrical nature of CPHPC allows it to bind to two molecules of AP (the SAP subunits). This allows five molecules of CPHPC to bind two SAP pentamers together by the B/binding face blocking the binding on to existing amyloid deposits.

References

References

  1. (2002). "Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis". Nature.
  2. "Pharmaceutical Formulations for the Treatment of Alzheimer's Disease".
  3. [http://www.medscape.com/viewarticle/532896_3 Reducing the Supply of Amyloid Fibril Precursor Proteins], ''MedScape Today''
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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