Surf Wiki
Save to docs
general/tetrapyrroles

From Surf Wiki (app.surf) — the open knowledge base

Coproporphyrinogen III

Coproporphyrinogen III is a metabolic intermediate in the biosynthesis of many compounds that are critical for living organisms, such as hemoglobin and chlorophyll. It is a colorless solid.

The compound is a porphyrinogen, a class of compounds characterized by a hexahydroporphine core with various side chains. The coproporphyrinogens have the outermost hydrogen atoms of the core replaced by four methyl groups (M) and four propionic acid groups (P). In coproporphyrogen III, the order around the outer ring is MP-MP-MP-PM. For comparison, coproporphyrinogen I has them in the sequence MP-MP-MP-MP. heme.

Biosynthesis and metabolism

In the main porphyrin biosynthesis pathway, coproporphyrinogen III is derived from uroporphyrinogen III by the action of the enzyme uroporphyrinogen III decarboxylase:

The conversion entails four decarboxylations, which turn the four acetic acid groups into methyl groups , with release of four carbon dioxide molecules.

Coproporphyrinogen III is further used as a substrate for the enzyme coproporphyrinogen III oxidase which oxidizes and further decarboxylates it to protoporphyrinogen IX.

References

References

  1. (November 2008). "Uroporphyrinogen decarboxylation as a benchmark for the catalytic proficiency of enzymes". Proc. Natl. Acad. Sci. U.S.A..
  2. {{cite encyclopedia. Paul R. Ortiz de Montellano. (2008). John Wiley & Sons
  3. (2000). "Molecular aspects of the inherited porphyrias". Journal of Internal Medicine.
  4. {{KEGG enzyme. 1.3.3.3
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

tetrapyrroles
Want to explore this topic further?

Ask Mako anything about Coproporphyrinogen III — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report