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Collagenous fibroma

Benign fibrous tumor

Summary

Benign fibrous tumor

Field	Value
specialty	Dermatology

Collagenous fibroma, also known as desmoplastic fibroblastoma, is a slow-growing, deep-set, benign fibrous tumor, usually located in the deep subcutis, fascia, aponeurosis, or skeletal muscle of the extremities, limb girdles, or head and neck regions. The World Health Organization in 2020 reclassified desmoplastic fibroblastoma/collagenous fibroma as a specific benign tumor type within the broad category of fibroblastic and myofibroblastic tumors.

Signs and symptoms

Clinically, the lesion is observed as a hard, well-circumscribed, lobulated, round to oval, or fibrous mass that has a sparkling gray-to-white aspect and appears fibrous on the cut surface. Patients with these tumors often appear with a history of a painless, slowly developing mass, often over a reasonably lengthy period of time. These tumors are mostly found in the subcutaneous and skeletal muscle tissues of the extremities. These tumors usually have a diameter of 1 to 20 cm, with a median diameter of 3 cm.

Diagnosis

Collagenous fibroma is characterized histopathologically by long, sweeping fascicles of uniformly spindled cells that range in size from moderately to hypercellular. Long, thick-walled arteries exhibiting perivascular stromal edema are seen. Gardner fibroma, nuchal-type fibroma, and desmoid tumor are examples of differential diagnoses.

The fibroblastic cells have strong vimentin immunohistochemistry. A small number of cells may exhibit positive immunoreactivity for alpha-smooth muscle actin and muscle-specific proteins. The cells resemble fibroblasts or myofibroblasts in terms of ultrastructure.

Treatment

Patients with collagenous fibroma who undergo marginal excision have good surgical results. Video-assisted surgery has been suggested as a substitute for traditional open surgery in the removal of tumors on the chest wall because it minimizes tissue damage and allows for a smaller incision.

References

James, William D.. (2006). "Andrews' diseases of the skin: clinical dermatology". Saunders Elsevier.
(April 2021). "The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives". Pathologica.
(May 1998). "Collagenous fibroma (desmoplastic fibroblastoma): report of four cases and review of the literature". Archives of Pathology & Laboratory Medicine.
(2018-01-05). "Diagnosis and Differential Diagnosis of Desmoplastic Fibroblastoma by Clinical, Radiological, and Histopathological Analyses". Ovid Technologies (Wolters Kluwer Health).
(September 1995). "Desmoplastic fibroblastoma. A report of seven cases". The American Journal of Surgical Pathology.
(1998). "Collagenous fibroma (desmoplastic fibroblastoma): A clinicopathologic analysis of 63 cases of a distinctive soft tissue lesion with stellate-shaped fibroblasts". Elsevier BV.
(2023-09-04). "Superficial desmoplastic fibroblastoma (collagenous fibroma): Clinicopathologic study of 11 cases". Wiley.
(2009). "Collagenous Fibroma (Desmoplastic Fibroblastoma) with Vertebral Body Erosion". Hindawi Limited.
(2012). "Collagenous fibroma (desmoplastic fibroblastoma) of the oral cavity". Medknow.
(2021). "An Update on Clinicopathological, Imaging and Genetic Features of Desmoplastic Fibroblastoma (Collagenous Fibroma)". In Vivo.
(2017-05-26). "Video-assisted thoracoscopic surgery en bloc chest wall resection". AME Publishing Company.
(2021). "An extremely rare case of desmoplastic fibroblastoma exhibiting rapid growth in the chest wall: a case report". Surgical Case Reports.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

dermal-and-subcutaneous-growths connective-and-soft-tissue-neoplasms benign-neoplasms

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