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Clotting time

Medical laboratory blood test

Summary

Medical laboratory blood test

FieldValue
NameClotting time
SpecialtyHaematology
MeshIDD014914
MedlinePlus003652

Methods

There are various methods for determining the clotting time, the prototype historical method being the capillary tube method. It is affected by calcium ion levels and many diseases. The normal range of clotting times is 2-8 minutes.

For the measurement of clotting time by the test tube method, blood is placed in a glass test tube and kept at 37°C. The required time for the blood to clot is measured.

There are several other methods, including testing for those on blood thinners, such as heparin or warfarin. Activated partial thromboplastin time (aPTT) is used for heparin studies and the normal range is 20–36 seconds, depending upon which type of activator is used in the study. Prothrombin time (PT) is used for warfarin studies and the normal values differ for men and women. Adult male PT normal range is 9.6–11.8 seconds, while adult females' normal range is 9.5–11.3 seconds. Internationalized normalized ratio (INR) is also a warfarin study, with therapeutic ranges of 2–3 for standard warfarin and 3–4.5 for high-dose warfarin. In a veterinary study of bovine animals, the mean ACT was 145 seconds with a range of 120–180 seconds. Standard deviations were 18 and 13 for the first and second sampling, respectively. Repeatability of the ACT was acceptable.

References

References

  1. (January 2015). "Robinson's Current Therapy in Equine Medicine". W.B. Saunders.
  2. (March 2013). "Mechanisms of fibrin polymerization and clinical implications". Blood.
  3. (2023). "StatPearls". StatPearls Publishing.
  4. (August 1958). "A micromethod for determining clotting time, using capillary blood and siliconized tubes.". The Journal of Laboratory and Clinical Medicine.
  5. (2016). "Bleeding Time (BT) and Clotting Time (CT)". BioScience.
  6. (2014). "Saunders comprehensive review for the NCLEX-RN examination". Elsevier Health Sciences.
  7. (1979). "Activated coagulation times of normal cows". Veterinary Clinical Pathology.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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