Clobenzorex

Chemistry

Synthesis

Condensation between amphetamine (1) and 2-chlorobenzaldehyde (2) gives a Schiff-base, CID:135056236 (3). Subsequent reduction with sodium borohydride completed the synthesis of clobenzorex (4).

Urinalysis

Clobenzorex can be detected by urine drug screening. It is one of many drugs that can cause a positive result for amphetamine in urine drug screening. It may be differentiated from use of amphetamine itself through testing for metabolites such as 4-hydroxyclobenzorex or enantiomeric analysis.

Legal Status

Brazil

In Brazil, clobenzorex is a controlled prohibited psychotropic (class A3).

Canada

In Canada, clobenzorex is not specifically listed per the Controlled Drugs and Substances Act.

Mexico

In Mexico, clobenzorex is available for sale over the counter at many Mexican pharmacies under the primary brand Asenlix, as well as generic trade names like Dinintel, Finedal, Rexigen, Itravil, all of which are available via prescription in India, and OTC in Mexico and Honduras, typically used as an appetite suppressant.

United Kingdom

In the United Kingdom, clobenzorex is a controlled drug (class B).

United States

Clobenzorex is not controlled under the Controlled Substances Act of 1970 nor is it controlled under the Federal Analogue Act, as it is a derivative of benzphetamine. It is not subject to import controls and is legal to import and possess for personal medical use, provided all of the following conditions are met:

1. It is used to treat a condition with no FDA-approved medications or an orphan drug does not effectively treat a condition, and the risks of use have not been determined to outweigh to benefits of treatment;
2. is not being deceptively and unlawfully marketed; and
3. is part of an ongoing medical treatment plan that began in a foreign country.

World Anti-Doping Agency

The use of clobenzorex is banned by the World Anti-Doping Agency for use during sports competitions as an athletic performance enhancer ("doping").

References

References

1. Anvisa. (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial". [[Diário Oficial da União]].
2. (2005). "Handbook of Forensic Drug Analysis.". Elsevier.
3. (February 1997). "Clobenzorex: evidence for amphetamine-like behavioral actions". Pharmacology, Biochemistry, and Behavior.
4. (January 1966). "[New derivatives of phenylisopropylamine: synthesis and study of their anorexic activity]". Annales Pharmaceutiques Françaises.
5. "New substituted benzylamines and their salts and process for preparation".
6. (July 1970). "Synthèse du chlorhydrate de (+)-N-(o-chlorobenzyl) α-methyl phénéthylamine marqué en position 7 par 14C (chlorhydrate de clobenzorex).". Journal of Labelled Compounds.
7. (2018-01-02). "Forensic Toxicology". Academic Press.
8. (2018-02-23). "On Call Psychiatry E-Book: On Call Series". Elsevier Health Sciences.
9. (2001-04-01). "Amphetamine, Clobenzorex, and 4-Hydroxyclobenzorex Levels Following Multidose Administration of Clobenzorex". Journal of Analytical Toxicology.
10. Anvisa. (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial". [[Diário Oficial da União]].
11. "Misuse of Drugs Act 1971 (c. 38): SCHEDULE 2: Controlled Drugs". Office of Public Sector Information.
12. Boos, Terrence. (April 6, 2023). "Clobenzorex Letter".
13. (28 June 2021). "Is it legal for me to personally import drugs?". Food and Drug Administration.
14. (September 2022). "World Anti-Doping Code International Standard Prohibited List 2023".