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Clear cell acanthoma

Field	Value
image	SkinTumors-P5280038.JPG
caption	Clear cell acanthoma (Degos)
specialty

Clear cell acanthoma (also known as Acanthome cellules claires of Degos and Civatte, Degos acanthoma, and Pale cell acanthoma) is a benign clinical and histological lesion initially described as neoplastic, which some authors now regard as a reactive dermatosis. It usually presents as a moist solitary firm, brown-red, well-circumscribed, 5 mm to 2 cm nodule or plaque on the lower extremities of middle-aged to elderly individuals. The lesion has a crusted, scaly peripheral collarette and vascular puncta on the surface; in dermoscopy this looks like "a string of pearls". It is characterized by slow growth, and may persist for years. The clinical differential diagnosis includes: dermatofibroma, inflamed seborrheic keratosis, pyogenic granuloma, basal-cell carcinoma, squamous cell carcinoma, verruca vulgaris, psoriatic plaque, and melanoma.

Histology

Clear cell acanthoma is characterized by a sharply demarcated psoriasiform epidermal hyperplasia composed of a proliferation of slightly enlarged keratinocytes, and basal cells with pale-staining glycogen-rich cytoplasm, mild spongiosis and scattered neutrophils, which may form small intraepidermal microabscesses. Oedematous dermal papillae are typically seen with increased vascularity and a mixed inflammatory infiltrate including lymphocytes, plasma cells and neutrophils.

Treatment

Simple surgical excision is curative.

References

Tiodorovic-Zivkovic, D. (2015). "Dermoscopy of clear cell acanthoma". J Am Acad Dermatol..
Odom, Richard B.. (2006). "Andrews' diseases of the skin: clinical dermatology". Saunders Elsevier.
Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. {{ISBN. 0-07-138076-0.

Info: Wikipedia Source

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epidermal-nevi,-neoplasms,-and-cysts

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