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Clazakizumab

Chemical compound

| Drugs.com = | elimination_half-life =

Clazakizumab (formerly ALD518 and BMS-945429), an investigational drug, is an aglycosylated, humanized rabbit monoclonal antibody against interleukin-6. Clazakizumab was developed by Bristol Myers Squib and Alder Biopharmaceuticals. A preliminary randomized, double-blind, placebo-controlled, phase 2 dose-ranging study of clazakizumab in psoriatic arthritis patients, funded by the manufacturer, suggested that clazakizumab may be an effective treatment option for musculoskeletal aspects of psoriatic arthritis; however, the antibody lacked a dose-response effect.

References

(2007). "Handbook of Therapeutic Antibodies, Volume 2". Wiley Blackwell.
(September 2016). "The efficacy and safety of clazakizumab, an anti-interleukin-6 monoclonal antibody, in a phase IIb study of adults with active psoriatic arthritis.". Arthritis Rheumatol.

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drugs-developed-by-bristol-myers-squibb antibodies experimental-monoclonal-antibodies

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