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Chronic eosinophilic leukemia

FieldValue
nameChronic eosinophilic leukemia
synonymsCEL
fieldhematology, oncology

Chronic eosinophilic leukemia is a form of cancer in which too many eosinophils are found in the bone marrow, blood, and other tissues. Most cases are associated with fusion genes. {{cite web |url=https://www.lecturio.com/concepts/chronic-eosinophilic-leukemia/| title=Chronic Eosinophilic Leukemia

Signs and symptoms

Signs and symptoms may include weight loss, fever, malaise, cough, skin and mucosal lesions, diarrhea, and peripheral neuropathy. Cardiac symptoms are also possible.

In cases associated with PDGFRB and FGFR1 mutations, splenomegaly is common. Lymphadenopathy is also common with FGFR1 mutations.

Infiltration of eosinophils causes organ damage.

Causes

Most cases of CEL are associated with rearrangements in PDGFRA, PDGFRB, or FGFR1.

CEL not otherwise specified (CEL NOS) is a form in which BCR-ABL1 fusion genes and PDGFRA, PDGFRB, and FGFR1 rearrangements are not found.

Diagnosis

For a diagnosis of CEL, hypereosinophilia with greater than 30% eosinophils is required. Serum IgE is usually normal. In cases associated with PDGFRB, serum vitamin B12 and tryptase may be elevated.

Prognosis

CEL associated with a mutation in PDGFRA is treatable with imatinib and has an excellent prognosis. On the other hand, CEL associated with FGFR1 mutations has a very poor prognosis. Progression can occur from CEL to AEL or AML in rare cases.

Epidemiology

Cases occur in people of all ages. The disease is more common in males than females.

References

References

  1. (2016-08-25). "Hematopathology".
  2. (2011). "Henry's Clinical Diagnosis and Management by Laboratory Methods". Elsevier.
  3. (2017-08-15). "Hematology: basic principles and practice".
  4. Stonecypher, Mark. (2013). "Hematopathology". Elsevier.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

chronic-myeloid-leukemia rare-cancers
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