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Chronic allograft nephropathy

Field	Value
name	Chronic allograft nephropathy
synonyms	Sclerosing/chronic allograft nephropathy
image	Chronic allograft nephropathy - intermed mag.jpg
width	250
caption	Micrograph of chronic allograft nephropathy. PAS stain.
field	Urology

Chronic allograft nephropathy (CAN) is a kidney disorder which is the leading cause of kidney transplant failure, occurring months to years after the transplant.

Symptoms and signs

CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.

Pathology

The histopathology is characterized by interstitial fibrosis, tubular atrophy, fibrotic intimal thickening of arteries and glomerulosclerosis.

Diagnosis

CAN is diagnosed by examination of tissue, e.g. a kidney biopsy.

References

(Sep 1999). "Chronic allograft nephropathy: An update.". Kidney Int.
(Jul 2005). "Chronic renal allograft rejection: pathophysiologic considerations.". Kidney Int.
(Mar 2006). "Chronic allograft nephropathy: current concepts and future directions.". Transplantation.
(2009). "Chronic allograft nephropathy". Springer Science and Business Media LLC.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

organ-transplantation kidney-diseases

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