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Cholesteryl ester

Dietary lipid

Summary

Dietary lipid

300px|thumb|right|Cholesteryl oleate, a member of the cholesteryl ester family Cholesteryl esters are a type of dietary lipid and are ester derivatives of cholesterol. The ester bond is formed between the carboxylate group of a fatty acid and the hydroxyl group of cholesterol. Cholesteryl esters have a lower solubility in water due to their increased hydrophobicity. Esters are formed by replacing at least one –OH (hydroxyl) group with an –O–alkyl (alkoxy) group. They are hydrolyzed by pancreatic enzymes, such as cholesterol esterase, to produce cholesterol and free fatty acids. They are associated with atherosclerosis.

Cholesteryl esters are found in human brains as lipid droplets which store and transport cholesterol. Increased levels of cholesteryl esters have been found in certain parts of the brain of people with Huntington's disease. Higher concentrations of cholesteryl esters have been found in the caudate and putamen, but not the cerebellum, of people with Huntington disease compared with levels in controls. Increase in cholesteryl esters has also been found in other neurological disorders like multiple sclerosis and Alzheimer's disease.

Transfer of cholesteryl ester

Cholesteryl esters are transported from high-density lipoproteins (HDLs) to low-density lipoproteins (LDLs) and very low-density lipoproteins (VLDLs) with cholesteryl ester transfer protein (CETP). The decrease in cholesteryl esters can lower HDL and increase LDL, which may be an indicator of cardiovascular problems, as indicated by intervention studies. Increasing HDL values has the potential to prevent mortality associated with cardiovascular risks such as atherosclerosis.

References

References

  1. (2011). "Lippincott's illustrated reviews, biochemistry". Wolters Kluwer Health.
  2. {{MeshName. Cholesterol+Esters
  3. (2020-11-20). "Cholesteryl ester levels are elevated in the caudate and putamen of Huntington's disease patients". Scientific Reports.
  4. "Illawarra Health and Medical Research Institute Researchers Report on Findings in Huntington Disease (Cholesteryl ester levels are elevated in the caudate and putamen of Huntington's disease patients) (Cholesteryl ester levels are elevated in ...)." ''Obesity, Fitness & Wellness Week'', 2020, p. 2684. ''Gale Academic OneFile'', link.gale.com/apps/doc/A643924682/AONE?u=cuny_hunter&sid=AONE&xid=6782d457. Accessed 2 May 2021.
  5. (October 2012). "Crystal Structures of Cholesteryl Ester Transfer Protein in Complex with Inhibitors". Journal of Biological Chemistry.
  6. (2 January 2010). "Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors". European Heart Journal.
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