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Cholest-4-en-3-one 26-monooxygenase

Class of enzymes

Class of enzymes

FieldValue
NameCholest-4-en-3-one 26-monooxygenase
EC_number1.14.13.141

Cholest-4-en-3-one 26-monooxygenase (, CYP125, CYP125A1, cholest-4-en-3-one 27-monooxygenase) is an enzyme with systematic name cholest-4-en-3-one,NADH:oxygen oxidoreductase (26-hydroxylating). This enzyme catalyses the following chemical reaction

: cholest-4-en-3-one + NADH + H+ + O2 \rightleftharpoons 26-hydroxycholest-4-en-3-one + NAD+ + H2O

Cholest-4-en-3-one 26-monooxygenase is a heme thiolate (P450) enzyme.

References

References

  1. (December 2009). "Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1". Molecular Microbiology.
  2. (December 2009). "The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection". The Journal of Biological Chemistry.
  3. (December 2009). "Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids". The Journal of Biological Chemistry.
  4. (August 2010). "Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one". Molecular Microbiology.
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ec-1.14.13
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