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Chlamydia muridarum

Species of bacterium

Species of bacterium

Chlamydia muridarum is an intracellular bacterial species that at one time was considered a biovar "mouse pneumonitis" (MoPn) inside of Chlamydia trachomatis. However, C. trachomatis naturally only infects humans and C. muridarum naturally infects only members of the family Muridae (includes both mice and hamsters, Alderton, 1996).

Two strains of Chlamydia muridarum, MoPn (originally named Nigg) and SFPD, have been isolated from mice and hamsters. Glycogen production by both strains has been demonstrated. The chromosome and extrachromosomal plasmid of MoPn have been sequenced.

Chlamydia muridarum MoPn binds mAbs recognizing Chlamydia trachomatis MOMP vs4 core epitope (T) LNPT (IA). DNA sequence analysis indicates that these mAbs should recognize SFPD and that Chlamydia trachomatis B-serogroup mAbs specific for the vs4 epitope IAGAG should recognize SFPD. MoPn was isolated in 1942 from the lungs of asymptomatic albino Swiss mice and was subsequently shown to be capable of producing disease in mice. SFPD was obtained from a hamster, concurrent with a causative agent of proliferative ileitis. MoPn has been shown to be sensitive to sulfadiazine.

In contrast to Chlamydia trachomatis, Chlamydia muridarum lacks a tryptophan operon. Due to this, Chlamydia muridarum responds to interferon gamma (IFN-γ) differently than Chlamydia trachomatis, which effects the degree to which the two different Chlamydia strains are inhibited in infected mice and humans, respectively.

Genome structure

The genome of several strains has been sequenced.

References

References

  1. (1999). "Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam. nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards for the identification of organisms". International Journal of Systematic Bacteriology.
  2. (15 March 2000). "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39.". Nucleic Acids Research.
  3. (June 2008). "The Chlamydia trachomatis Plasmid Is a Transcriptional Regulator of Chromosomal Genes and a Virulence Factor". Infection and Immunity.
  4. (Jul 1996). "Species-, serogroup-, and serovar-specific epitopes are juxtaposed in variable sequence region 4 of the major outer membrane proteins of some Chlamydia trachomatis serovars.". Infect Immun.
  5. (Jan 1942). "An Unidentified Virus Which Produces Pneumonia and Systemic Infection in Mice". Science.
  6. (Mar 2011). "Vaccination against Chlamydia Genital Infection Utilizing the Murine C. muridarum Model". Infection and Immunity.
  7. (Mar 2011). "Vaccination against Chlamydia Genital Infection Utilizing the Murine C. muridarum Model". Infection and Immunity.
  8. (2015). "Molecular Medical Microbiology". Elsevier.
  9. Read TD. (2000). "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39". Nucleic Acids Res.
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chlamydiota bacteria-described-in-1999
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