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Ceftiofur

Chemical compound

Summary

Chemical compound

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Ceftiofur is an antibiotic of the cephalosporin type (third generation), licensed for use in veterinary medicine. It was first described in 1987. It is marketed by pharmaceutical company Zoetis as Excenel, Naxcel, and Excede and is also the active ingredient in that company's Spectramast LC (lactating cow formulation) and Spectramast DC (dry cow formulation) product.

It is resistant to the antibiotic resistance enzyme beta-lactamase, and has activity against both Gram-positive and Gram-negative bacteria. Escherichia coli strains resistant to ceftiofur have been reported.

The metabolite desfuroylceftiofur also has antibiotic activity. The two compounds are measured together to measure for antibiotic activity in milk (alongside other antibiotics).

References

References

  1. (20 October 2009). "Naxcel EPAR".
  2. (24 May 2005). "Naxcel PI".
  3. (1987). "Ceftiofur sodium, a broad-spectrum cephalosporin: evaluation ''in vitro'' and ''in vivo'' in mice". Am. J. Vet. Res..
  4. "Pfizer Animal Health Dairy Information on Products and Solutions".
  5. (2006). "Molecular epidemiology of ceftiofur-resistant ''Escherichia coli'' isolates from dairy calves". Appl. Environ. Microbiol..
  6. (July 1996). "In vitro activity of ceftiofur and its primary metabolite, desfuroylceftiofur, against organisms of veterinary importance". Journal of Veterinary Diagnostic Investigation.
  7. "BetaStar Plus / For beta-lactam antibiotics / Product information sheet". Neogen.
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

cephalosporin-antibiotics 2-furyl-compounds thiazoles ketoxime-ethers veterinary-drugs
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