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Cefpodoxime

Antibiotic

Summary

Antibiotic

| Drugs.com =

| elimination_half-life = 2 hours

Cefpodoxime is an oral, third-generation cephalosporin antibiotic available in various generic preparations. It is active against both Gram-positive and Gram-negative organisms with notable exceptions including Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. It is typically used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.

Cefpodoxime inhibits peptidoglycan synthesis in bacterial cell walls. It has an oral bioavailability of approximately 50%, which is increased when taken with food. It has an elimination half-life of 2-3 hours in adults, which is prolonged in renal failure. Approved indications include community acquired pneumonia, uncomplicated skin and skin structure infections, and uncomplicated urinary tract infections.

It was patented in 1980 and approved for medical use in 1989.

Spectrum of bacterial susceptibility and resistance

Cefpodoxime has been used to treat gonorrhoea, tonsillitis, pneumonia, and bronchitis. The following minimum inhibitory concentrations have been reported:

  • Haemophilus influenzae: ≤0.03 – 1 μg/ml
  • Neisseria gonorrhoeae: 0.004 – 0.06 μg/ml
  • Streptococcus pyogenes: ≤0.004 – 2 μg/ml

Brand names

Zoetis markets cefpodoxime proxetil under the trade name Simplicef for veterinary use, and Finecure in India markets the drug as Cefpo.

  • Vantin (by Pfizer) in suspension or tablet form.
  • Toraxim (by Delta Pharma Ltd., Bangladesh)
  • Trucef (by Renata Limited, Bangladesh)
  • Tricef (by Alkaloid Skopje, North Macedonia)
  • Orelox (by Sanofi-Aventis)
  • MAPDOX-CV: Combination cefpodoxime–clavulanic acid
  • MONOTAX O (cefpodoxime)/MONOTAX CV (cefpodoxime–clavulanic acid) by Zydus Healthcare Ltd.
  • ACXIME 200/CV (by Allencia Biosciences, India)
  • POSTPOD-50 (cefpodoxime 50mg/5ml) by Laafon Galaxy Pharmaceuticals

References

References

  1. (2006). "Analogue-based Drug Discovery". John Wiley & Sons.
  2. "Cefpodoxime, Free Acid Susceptibility and Minimum Inhibitory Concentration (MIC) Data".
  3. "Pharmaceuticals Manufacturer, Marketer, Pharmaceutical Manufacturing Company India".
  4. "Anti Biotics and Anti Bacterial". Finecurepharmaceuticalsltd.
  5. "Vantin – Drugs.com".
  6. "Orelox – Drugs.com".
  7. "Postpod dry syrup".
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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