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Cefalotin

Chemical compound

Summary

Chemical compound

| Drugs.com = | elimination_half-life = 30 minutes to 1 hour

Cefalotin (INN) or cephalothin (USAN) is a first-generation cephalosporin antibiotic with broad spectrum antibiotic activity. It was the first cephalosporin marketed (1964) and continues to be widely used. Cefalotin is used for bacterial infections of the respiratory tract, urinary tract, skin, soft tissues, bones and joints, sepsis, peritonitis, osteomyelitis, mastitis, infected wounds, and post-operational infections.

It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agents cefalexin and cefadroxil. Cefalotin sodium is marketed as Keflin (Lilly) and under other trade names.

The compound is a derivative of thiophene-2-acetic acid.

References

References

  1. (July 2002). "Review of the use of cephalosporins in children with anaphylactic reactions from penicillins". The Canadian Journal of Infectious Diseases.
  2. (2006). "Synthesis of Essential Drugs".
  3. (21 February 2008). "Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph". OUP Oxford.
  4. {{drugs.com. international. cefalotin: Cefalotin
  5. (2006). "Ullmann's Encyclopedia of Industrial Chemistry". Wiley-VCH.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

cephalosporin-antibiotics drugs-developed-by-eli-lilly-and-company thiophenes acetate-esters
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