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CD120

Protein family

CD120
Summary

Protein family

FieldValue
Nametumor necrosis factor receptor superfamily, member 1A
HGNCid11916
SymbolTNFRSF1A
AltSymbolsCD120a, TNFR1
EntrezGene7132
OMIM191190
RefSeqNM_001065
UniProtP19438
Chromosome12
Armp
Band13.2

CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).

Receptor subtypes

There are two variants of the receptor, each encoded by a separate gene:

  • CD120a - TNFR1 - TNFR superfamily member 1A
  • CD120b - TNFR2 - TNFR superfamily member 1B

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior, and is involved in neurotoxic processes. Elevated levels of TNFR1 has been found in severe mental disorders.

Signaling pathway

TNF]]-R1. Dashed grey lines represent multiple steps

References

References

  1. (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell.
  2. (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology.
  3. (January 2009). "The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior". Psychopharmacology.
  4. (2008). "TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease". J Neuroinflammation.
  5. (November 2009). "Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor". Bipolar Disord.
Wikipedia Source

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