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CCA tRNA nucleotidyltransferase

Enzyme

Summary

Enzyme

FieldValue
NameCCA tRNA nucleotidyltransferase
EC_number2.7.7.72

CCA tRNA nucleotidyltransferase (, CCA-adding enzyme, tRNA adenylyltransferase, tRNA CCA-pyrophosphorylase, tRNA-nucleotidyltransferase, transfer-RNA nucleotidyltransferase, transfer ribonucleic acid nucleotidyl transferase, CTP(ATP):tRNA nucleotidyltransferase, transfer ribonucleate adenylyltransferase, transfer ribonucleate adenyltransferase, transfer RNA adenylyltransferase, transfer ribonucleate nucleotidyltransferase, ATP (CTP):tRNA nucleotidyltransferase, ribonucleic cytidylic cytidylic adenylic pyrophosphorylase, transfer ribonucleic adenylyl (cytidylyl) transferase, transfer ribonucleic-terminal trinucleotide nucleotidyltransferase, transfer ribonucleate cytidylyltransferase, ribonucleic cytidylyltransferase, -C-C-A pyrophosphorylase, ATP(CTP)-tRNA nucleotidyltransferase, tRNA adenylyl(cytidylyl)transferase, CTP:tRNA cytidylyltransferase) is an enzyme with systematic name CTP,CTP,ATP:tRNA cytidylyl,cytidylyl,adenylyltransferase. This enzyme catalyses the following chemical reaction

: a tRNA precursor + 2 CTP + ATP \rightleftharpoons a tRNA with a 3' CCA end + 3 diphosphate (overall reaction) :(1a) a tRNA precursor + CTP \rightleftharpoons a tRNA with a 3' cytidine end + diphosphate :(1b) a tRNA with a 3' cytidine + CTP \rightleftharpoons a tRNA with a 3' CC end + diphosphate :(1c) a tRNA with a 3' CC end + ATP \rightleftharpoons a tRNA with a 3' CCA end + diphosphate

The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence.

References

References

  1. (August 1977). "Purification and some properties of Escherichia coli tRNA nucleotidyltransferase". The Journal of Biological Chemistry.
  2. (June 1998). "CCA addition by tRNA nucleotidyltransferase: polymerization without translocation?". The EMBO Journal.
  3. (May 2003). "Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization". Journal of Molecular Biology.
  4. (August 2004). "The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities". The Journal of Biological Chemistry.
  5. (April 2010). "CCA addition to tRNA: implications for tRNA quality control". IUBMB Life.
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-2.7.7
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