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Carnivore bocaparvovirus 1
Species of virus
Species of virus
Carnivore bocaparvovirus 1, formerly Canine minute virus (or minute virus of canines; MVC) is a species of Bocaparvovirus of the family Parvoviridae that infects dogs. It is similar to bovine parvovirus in its protein structure and DNA. A virus causing respiratory disease in humans has been called human bocavirus due to its similarity to these viruses. Canine minute virus was originally discovered in Germany in 1967 in military dogs, although it was originally thought to not cause disease. Dogs and puppies are infected orally, and the virus is spread transplacentally to the fetuses. Symptoms are seen most commonly between the ages of one and three weeks and include severe diarrhea, difficulty breathing, and anorexia. In severe cases, illness can be fatal.
In experimental infections, the virus is spread transplacentally when the dam is infected between 25 and 30 days of gestation and can result in abortion. When the dam is infected between 30 and 35 days, the puppies were sometimes born with myocarditis and anasarca.
Virology
The genome is 5.4 kilobases in length, with palindromic termini. A single P6 promoter, through the mechanisms of alternative splicing and alternative polyadenylation, directs the transcription of two non-structural proteins (NS1 and NP1) and two capsid proteins (VP1 and VP2). The NS1 protein is essential for genome replication. The NP1 protein, unique to the Bocaparvovirus genus, appears to be critical for optimal viral replication, as the NP1-knockout mutant of MVC exhibits severe impairment in replication.
References
References
- "ICTV Taxonomy history: ''Carnivore bocaparvovirus 1''".
- (2002). "The canine minute virus (minute virus of canines) is a distinct parvovirus that is most similar to bovine parvovirus". Virology.
- McIntosh K. (2006). "Human bocavirus: developing evidence for pathogenicity". J Infect Dis.
- Carmichael, L.. (2004). "Neonatal Viral Infections of Pups: Canine Herpesvirus and Minute Virus of Canines (Canine Parvovirus-1)". Recent Advances in Canine Infectious Diseases.
- Hashimoto A. (1999). "Canine parvovirus type-1 (MVC): Pathomorphological studies on the experimentally infected fetus and MVC-infected cultured cells". Canine Infectious Diseases: From Clinics to Molecular Pathogenesis.
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