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Carbonyl cyanide m-chlorophenyl hydrazone

Chemical compound

Summary

Chemical compound

Carbonyl cyanide m-chlorophenyl hydrazone (CCCP; also known as ) is a chemical inhibitor of oxidative phosphorylation. It is a nitrile, hydrazone and protonophore. In general, CCCP causes the gradual destruction of living cells and death of the organism,

References

(July 2009). "C. elegans longevity pathways converge to decrease mitochondrial membrane potential". Mechanisms of Ageing and Development.
(December 2020). "Targeting metabolic pathways for extension of lifespan and healthspan across multiple species". Ageing Research Reviews.
(2018). "Mitohormesis, an Antiaging Paradigm". International Review of Cell and Molecular Biology.
(November 10, 2021). "Membrane-Activated Fluorescent Probe for High-Fidelity Imaging of Mitochondrial Membrane Potential". ACS Sensors.
(2017). "The pharmacological regulation of cellular mitophagy". Nature Chemical Biology.
(2013). "The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells.". Autophagy.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

nitriles hydrazones 3-chlorophenyl-compounds ionophores uncouplers

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