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C-type lectin

A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin. The C-type designation is from their requirement for calcium for binding. Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.

Classification

Drickamer et al. classified C-type lectins into seven subgroups (I to VII) based on the order of the various protein domains in each protein. This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV). Most recently, three further subgroups were added (XV to XVII).

Group	Name	Associated domains
I	Lecticans	EGF, Sushi, Ig and Link domains
II	Asialoglycoprotein and DC receptors	None
III	Collectins	None
IV	Selectins	Sushi and EGF domains
V	NK - cell receptors	None
VI	Multi-CTLD endocytic receptors	FnII and Ricin domains
VII	Reg group	None
VIII	Chondrolectin, Layilin	None
IX	Tetranectin	None
X	Polycystin	WSC, REJ, PKD domains
XI	Attractin (ATRN)	PSI, EGF and CUB domains
XII	Eosinophil major basic protein (EMBP)	None
XIII	DGCR2	None
XIV	Thrombomodulin, CD93, CD248, CLEC14A	EGF domains
XV	Bimlec	None
XVI	SEEC	SCP and EGF domains
XVII	CBCP/Frem1/QBRICK	CSPG repeats and CalX-beta domains

CLECs include:

CLEC1A, CLEC1B
CLEC2A, CLEC2B, CD69 (CLEC2C), CLEC2D, CLEC2L
CLEC3A, CLEC3B
CLEC4A, CLEC4C, CLEC4D, CLEC4E, CLEC4F, CLEC4G, ASGR1 (CLEC4H1), ASGR2 (CLEC4H2), FCER2 (CLEC4J), CD207 (CLEC4K), CD209 (CLEC4L), CLEC4M
CLEC5A
CLEC6A
CLEC7A
OLR1 (CLEC8A)
CLEC9A
CLEC10A
CLEC11A
CLEC12A, CLEC12B
CD302 (CLEC13A), LY75 (CLEC13B), PLA2R1 (CLEC13C), MRC1 (CLEC13D), MRC2 (CLEC13E)
CLEC14A
CLEC16A
CLEC17A

The "NK Cell lectin-like receptors" are a very closely related group:

KLRA1
KLRB1 (CLEC5B)
KLRC1, KLRC2, KLRC3, KLRC4
KLRD1
KLRF1 (CLEC5C)
KLRG1 (CLEC15A), KLRG2 (CLEC15B)
KLRK1

Additional proteins containing this domain include:

AGC1; ATRNL1
BCAN
CD248; CD72; CD93; CHODL; CL-K1-Ia; CL-K1-Ib; CL-K1-Ic; CLECSF5; COLEC10; COLEC11; COLEC12; CSPG3
FCER2; FREM1; HBXBP;
LAYN; LOC348174; LOC728276
MAFA; MBL2; MGC34761; MICL; MRC1L1
OLR1
PAP; PKD1; PKD1L2; PLA2R1; PRG2; PRG3
REG1A; REG1B; REG3A; REG3G; REG4
SELE; SELL; SELP; SFTPA1; SFTPA2; SFTPA2B; SFTPD; SRCL
THBD
VCAN

References

(April 2004). "X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure". Biochemistry.
(September 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology.
(December 2005). "The C-type lectin-like domain superfamily". FEBS J..
{{MeshName. C-Type+Lectin
Drickamer K. (October 1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol..
(May 2009). "Necrosis: C-type lectins sense cell death". Curr. Biol..
Drickamer K. (1993). "Evolution of Ca(2+)-dependent animal lectins". Prog. Nucleic Acid Res. Mol. Biol..
(2002). "Genomic analysis of C-type lectins". Biochem. Soc. Symp..
(2019). "C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation.". FEBS Journal.
{{MeshName. NK+Cell+Lectin-Like+Receptors

Wikipedia Source

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c-type-lectins human-proteins protein-domains single-pass-transmembrane-proteins

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