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Butaperazine

Typical antipsychotic

Butaperazine
Summary

Typical antipsychotic

Butaperazine (Repoise, Tyrylen) is a typical antipsychotic of the phenothiazine class. It was approved in 1967, and possibly discontinued in the 1980s.

Synthesis

Synthesis of butaperazine

Butaperazine can be synthesized starting from 2-butyrylphenothiazine (1). It is prepared in a manner that is comparable to the method used in the synthesis of propiomazine and propiopromazine. The phenothiazine is alkylated with 1-(γ-chloropropyl)-4-methylpiperazine (2), which is prepared in the conventional way by alkylating 1-methylpiperazine with 1-bromo-3-chloropropane.

References

References

  1. Anvisa. (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial". [[Diário Oficial da União]].
  2. (December 1968). "Evaluation of a new antipsychotic agent. Butaperazine maleate (repoise maleate)". JAMA.
  3. Dr Ulrich Hoerlein, Dr Klaus-Heinz Risse, Dr Wolfgang Wirth, {{Cite patent. DE. 1120451 (1961 to Bayer Ag).
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

phenothiazines 4-methylpiperazin-1-yl-compounds aromatic-ketones typical-antipsychotics propyl-compounds
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