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Bronchorrhea


Bronchorrhea is the production of more than 100 mL per day of watery sputum. Chronic bronchitis is a common cause, but it may also be caused by asthma, pulmonary contusion, cite journal |vauthors=Gavelli G, Canini R, Bertaccini P, Battista G, Bnà C, Fattori R |title=Traumatic injuries: imaging of thoracic injuries |journal=European Radiology |volume=12 |issue=6 |pages=1273–1294 |date=June 2002 |pmid=12042932 |doi=10.1007/s00330-002-1439-6 |s2cid=1919039 |url= bronchiectasis, tuberculosis, cancer, scorpion stings, severe hypothermia and poisoning by organophosphates and other poisons. Massive bronchorrhea may occur in either bronchioloalveolar carcinoma, or in metastatic cancer that is growing in a bronchioloalveolar pattern. It commonly occurs in the setting of chest wall trauma, in which setting it can cause lobar atelectasis. TOC

Treatment

Treatment options for bronchorrhea vary depending on the inciting cause; they include:

  • gefitinib - epidermal growth factor receptor tyrosine kinase inhibitor
  • indomethacin
  • corticosteroids
  • octreotide
  • radiation therapy
  • bronchoscopy as is often done in the post traumatic setting.

References

for an explanation of how to generate footnotes using the tags--

References

  1. (1995). "A case of pancreatic carcinoma causing massive bronchial fluid production and electrolyte abnormalities". Chest.
  2. (1988). "Chemical properties of bronchorrhea sputum in bronchial asthma". Chest.
  3. (1994). "Bronchorrhea from diffuse lymphangitic metastasis of colon carcinoma to the lung". Chest.
  4. (2002). "[A case of suspected lung metastasis of pancreatic carcinoma with bronchorrhea similar to bronchioloalveolar carcinoma]". Nihon Kokyuki Gakkai Zasshi.
  5. (2005). "Teaching atlas of chest imaging". Thieme.
  6. (2005). "Gefitinib inhibits MUC5AC synthesis in mucin-secreting non-small cell lung cancer cells". Lung Cancer.
  7. (2005). "Novel effects of gefitinib on mucin production in bronchioloalveolar carcinoma; two case reports". Lung Cancer.
  8. (2005). "Prompt control of bronchorrhea in patients with bronchioloalveolar carcinoma treated with gefitinib (Iressa)". Support Care Cancer.
  9. Takao, Motoshi. (2003). "Successful treatment of persistent bronchorrhea by gefitinib in a case with Recurrent Bronchioloalveolar Carcinoma: a case report". World J Surg Oncol.
  10. (2003). "A report of two bronchioloalveolar carcinoma cases which were rapidly improved by treatment with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 ("I[res]sa")". Cancer Science.
  11. (2000). "Inhaled indomethacin in bronchorrhea in bronchioloalveolar carcinoma: role of cyclooxygenase". Chest.
  12. (1999). "Successful treatment of refractory bronchorrhea by inhaled indomethacin in two patients with bronchioloalveolar carcinoma". Chest.
  13. (1992). "Effect of indomethacin on bronchorrhea in patients with chronic bronchitis, diffuse panbronchiolitis, or bronchiectasis". Am Rev Respir Dis.
  14. (2002). "Treatment of bronchorrhea by corticosteroids in a case of bronchioloalveolar carcinoma producing CA19-9". Intern Med.
  15. (2006). "Successful treatment of bronchorrhea with octreotide in a patient with adenocarcinoma of the lung". J Pain Symptom Manage.
  16. (1988). "Palliation of massive bronchorrhea". Chest.
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