Bovine coronavirus

Virology

BCoV has 95% similarity with human coronavirus OC43 and 93% to porcine hemagglutinating encephalomyelitis virus. According to a 2006 study, those three strains may have diverged during the 19th century, while all circulating BCoV lineages had a most recent common ancestor around 1940s, with all earlier bovine lineages extinct.

An earlier article by the same authors compared BCoV and HCoV-OC43, and several methods yielded most probable divergence dates around 1890, leading authors to speculate that an introduction of the former strain to the human population might have caused the 1889–1890 flu pandemic.

Clinical signs and diagnosis

Infection normally occurs in calves between the ages of one week and three months. Gastrointestinal signs include profuse diarrhea, dehydration, depression, reduced weight gain and anorexia. Respiratory infection in the calf produces a serous to purulent nasal discharge. Clinical signs may worsen with secondary bacteria infection.

Infection in adults is normally subclinical, the exception being with winter dysentery, which affects housed cattle over the winter months. Clinical signs include profuse diarrhea and a significant drop in milk yield is seen in winter dysentery outbreaks.

A presumptive diagnosis can be made based on the history and clinical signs. Definitive diagnosis of an enteric coronavirus infection is achieved by performing electron microscopy or an ELISA on a faecal or tissue sample. In respiratory disease, diagnosis is confirmed by performing a direct fluorescent antibody test on nasal washes – which identifies the viral antigen.

The haemagglutination inhibition test can be used to establish the strain of coronavirus.

Treatment and control

Animals should be treated symptomatically. The disease can be controlled by vaccinating the dam with a live vaccine (ATCvet code QI02) whilst she is pregnant as this provides antibodies to the virus in the colostrum. Additional management factors such as ensuring adequate colostrum intake in newborn calves, using appropriate hygiene methods and ventilation of housing reduce disease incidence.

References

References

1. (2009). "ICTV 9th Report (2011) New ''Coronaviridae''".
2. (2011). "Bovine coronavirus (BCV) infections in transported commingled beef cattle and sole-source ranch calves". Canadian Journal of Veterinary Research.
3. (August 2018). "Genetic diversity of BCoV in Brazilian cattle herds". Veterinary Medicine and Science.
4. "Taxonomy browser (Betacoronavirus 1)".
5. (24 August 2010). "Coronavirus Genomics and Bioinformatics Analysis". Viruses.
6. "History of the taxon: Species: ''Betacoronavirus gravedinis'' (2024 Release, MSL #40)". International Committee on Taxonomy of Viruses.
7. (29 September 2016). "Structure, Function, and Evolution of Coronavirus Spike Proteins". Annual Review of Virology.
8. (2015). "Coronaviruses".
9. (2006). "Evolutionary History of the Closely Related Group 2 Coronaviruses: Porcine Hemagglutinating Encephalomyelitis Virus, Bovine Coronavirus, and Human Coronavirus OC43". Journal of Virology.
10. (2005). "Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus Transmission Event". Journal of Virology.