Surf Wiki
Save to docs
general/sunscreening-agents

From Surf Wiki (app.surf) — the open knowledge base

Bisoctrizole

-29(41(9,10)25-39(4,5)6)23-35(37(27)49)47-44-32-17-13-14-18-33(32)45-47/h11-18,20-23,48-49H,19,24-25H2,1-10H3 29(41(9,10)25-39(4,5)6)23-35(37(27)49)47-44-32-17-13-14-18-33(32)45-47/h11-18,20-23,48-49H,19,24-25H2,1-10H3}}

Bisoctrizole (INN/USAN, marketed by BASF as Tinosorb M, by DSM Nutritional Products as Parsol Max, by Everlight Chemical as Eversorb M, and by MPI as Milestab 360, INCI methylene bis-benzotriazolyl tetramethylbutylphenol) is a phenolic benzotriazole that is added to sunscreens to absorb UV rays. It is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. It also reflects and scatters UV.

Bisoctrizole is what is termed a hybrid UV absorber, which has been described as an organic UV filter produced in microfine organic particles (

Hence, bisoctrizole is formulated in sunscreen preparations as a 50% suspension, the absorber added to the water phase, and mineral micropigments usually added to the oil phase. The bisoctrizole particles are stabilized by the surfactant decyl glucoside. The compound shows very little photodegradation, and has a stabilizing effect on other UV absorbers, octyl methoxycinnamate (octinoxate) in particular.

In primary research reports, bisoctrizole has been reported to minimally penetrate skin, and has been described as lacking estrogenic effects in vitro.

Bisoctrizole has not yet been approved by the U.S. Food and Drug Administration (FDA), but is approved in the EU and other parts of the world.

References

References

  1. [[World Health Organization. (2005). "Recommended International Nonproprietary Names: List 54, International Nonproprietary Names for Pharmaceutical Substances (INN) [Entry 'bisoctrizolum']". WHO Drug Information.
  2. National Library of Medicine Staff. (July 5, 2022). "Bisoctrizole".
  3. Latha, MS. (January 2013). "Sunscreening Agents A Review". Journal of Clinical and Aesthetic Dermatology.
  4. Ciba Staff. (July 5, 2022). "TINOSORB® M, Broad-spectrum UV Filter for the Water Phase".
  5. Herzog, B.. (July 2022). "In vivo and in vitro assessment of UVA protection by sunscreen formulations containing either butyl methoxy dibenzoyl methane, methylene bis-benzotriazolyl tetramethylbutylphenol, or microfine ZnO". International Journal of Cosmetic Science.
  6. (July 2022). "In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen". Skin Pharmacol Physiol.
  7. (December 2001). "Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S". [[Regul Toxicol Pharmacol]].
  8. Kapes, Beth. (July 1, 2005). "Docs Rally for Better Sun Protection".
  9. "Eur-Lex.Europa.eu PDF".
  10. [https://web.archive.org/web/20070831075404/http://tga.gov.au/docs/pdf/argom_10.pdf Australian Regulatory Guidelines for OTC Medicines, Chapter 10.]{{full. (July 2022)
Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

sunscreening-agents benzotriazoles phenols
Want to explore this topic further?

Ask Mako anything about Bisoctrizole — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report