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BDPC

Synthetic opioid

Synthetic opioid

| elimination_half-life =

70895-01-1 (HCl)

BDPC (systematic name 4-(4-bromophenyl)-4-(dimethylamino)-1-(2-phenylethyl)cyclohexanol; also known as bromadol) is a potent fully synthetic opioid with a distinctive arylcyclohexylamine chemical structure. It was developed by Daniel Lednicer at Upjohn in the 1970s. Initial studies estimated that it was around 10,000 times the potency of morphine in animal models. However, later studies using more modern techniques assigned a value of 504 times the potency of morphine for the more active trans-isomer. This drug was first seized along with three kilograms of acetylfentanyl in an April 25, 2013 police action in Montreal, Canada, and has reportedly continued to be available on the designer drug market internationally. Analogues where the para-bromine is replaced by chlorine or a methyl group retain similar activity, while the meta-hydroxyl derivative demonstrated robust antagonist activity.

References

References

  1. "4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use".
  2. (October 1979). "4-(p-Bromophenyl)-4-(dimethylamino)-1-phenethylcyclohexanol, an extremely potent representative of a new analgesic series". [[Journal of Medicinal Chemistry]].
  3. (May 2003). "Opioid activity of C8813, a novel and potent opioid analgesic". [[Life Sciences (journal).
  4. (May 13, 2013). "Extremely potent painkiller hits Montreal black market". CBC News.
  5. (January 2019). "The search for the "next" euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning". Forensic Toxicology.
  6. (November 2020). "In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances". [[Archives of Toxicology]].
  7. (April 1981). "4-amino-4-arylcyclohexanones and their derivatives: a novel class of analgesics. 2. Modification of the carbonyl function". [[Journal of Medicinal Chemistry]].
  8. (March 1981). "4-aryl-4-aminocyclohexanones and their derivatives, a novel class of analgesics. 3. m-Hydroxyphenyl derivates". [[Journal of Medicinal Chemistry]].
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arylcyclohexylamines dimethylamino-compounds mu-opioid-receptor-agonists 4-bromophenyl-compounds synthetic-opioids
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