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Basaloid follicular hamartoma

Field	Value
name	Basaloid follicular hamartoma
image	SkinTumors-P6040183.JPG
caption	Basaloid hamartoma
field	Dermatology

Basaloid follicular hamartoma is a cutaneous condition characterized as distinctive benign adnexal tumor that has several described variants. It manifest as small tan or brown coloured papules in the trunk, pubic area, face, scalp, and axilla.

Basaloid follicular hamartoma is associated with a variety of disorders and is caused by mutation in the PTCH gene. The diagnosis is made based on histopathological examination.

Signs and symptoms

Basaloid follicular hamartoma manifests as multiple 1- to 2mm tan-to-brown-colored papules located on the pubic area, trunk, axilla, scalp, and face.

Causes

Basaloid follicular hamartoma can be hereditary or acquired.

Associated conditions include cystic fibrosis, systemic lupus erythematosus, myasthenia gravis, hypohidrosis, hypotrichosis, palmar pitting, and alopecia.

Basaloid follicular hamartoma is caused by a mutation in the chromosome 9q23 patch (PTCH) gene, which is also the gene responsible for nevoid basal cell carcinoma syndrome.

Diagnosis

The diagnosis of basaloid follicular hamartoma lesions requires a histopathological investigation. Histopathological features include basaloid epithelial cells in the papillary dermis form multifocal islands and branching cords, some of which are attached to the epidermis and dilated hair follicles.

Treatment

Various interventions, including photodynamic therapy, carbon dioxide laser, and surgery, have been suggested.

References

(2006). "Andrews' Diseases of the Skin: Clinical Dermatology". Saunders Elsevier.
(2024-03-14). "Basaloid Follicular Hamartoma: A Case Report and a Novel Cosmetic Treatment". Matrix Medical Communications.
(2010-11-09). "Congenital Systematized Basaloid Follicular Hamartoma with Microphthalmia and Hemimegalencephaly". Wiley.
(2015). "Generalized Basaloid Follicular Hamartoma Syndrome". Ovid Technologies (Wolters Kluwer Health).
(2022). "Basaloid follicular hamartoma associated with follicular mucinosis and inflammation". Elsevier BV.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

epidermal-nevi,-neoplasms,-and-cysts

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