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Balsalazide

Anti-inflammatory drug

Balsalazide

Anti-inflammatory drug

| Drugs.com =

| elimination_half-life = 12hr

Balsalazide is an anti-inflammatory drug used in the treatment of inflammatory bowel disease. It is sold under the brand names Giazo, Colazal in the US and Colazide in the UK. It is also sold in generic form in the US by several generic manufacturers.

It is usually administered as the disodium salt. Balsalazide is a prodrug of mesalazine, also known as 5-aminosalicylic acid, or 5-ASA. The advantage of balsalazide over mesalazine in the treatment of ulcerative colitis is believed to be due to balsalazide not being metabolized in the small intestine; it can thus reach the large intestine intact, where it is then metabolized to mesalazine. It is in the category of disease-modifying antirheumatic drugs (DMARDs) family of medications. It is unclear exactly how it works. TOC

Synthesis

Ex 3 is actually for Ipsalazide. See Ex 4 for Balsalazide proper. Same protocol but uses β-Alanine.

number=2080796}} (1986).
  1. Starting material is 4-aminohippuric acid, obtained by coupling para-aminobenzoic acid and glycine.
  2. That product is then treated with nitrous acid to give the diazonium salt.
  3. Reaction of this species with salicylic acid proceeds at the position para to the phenol to give balsalazide.

References

References

  1. (3 January 2019). "Colazide 750mg Capsules - Summary of Product Characteristics (SmPC)".
  2. (December 2001). "Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses". Gut.
  3. "Sulfasalazine". The American Society of Health-System Pharmacists.
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gastroenterology azo-compounds salicylic-acids benzamides propionic-acids
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