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Bacterial initiation factor 2

InterPro protein family

Bacterial initiation factor-2 is a bacterial initiation factor.

IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet-tRNAf binds to the IF2 then IF2 transfers the tRNA into the partial P site. When the 50S subunit joins, it hydrolyzes GTP to GDP and Pi, causing a conformational change in the IF2 that causes IF2 to release and allow the 70S ribosome to form.

Human mitochondria use a nuclear-encoded homolog, MTIF2, for translation initiation.

References

{{MeshName. Prokaryotic+Initiation+Factor-2
(July 2018). "Mitochondrial transcription and translation: overview". Essays in Biochemistry.

Info: Wikipedia Source

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protein-biosynthesis gene-expression

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