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Azlocillin

Beta-lactam antibiotic

Azlocillin
Summary

Beta-lactam antibiotic

| Drugs.com =

Azlocillin is an acyl ampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. Azlocillin is similar to mezlocillin and piperacillin. It demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa, and, in contrast to most cephalosporins, exhibits activity against enterococci.

Spectrum of bacterial susceptibility

Azlocillin is considered a broad spectrum antibiotic and can be used against a number of Gram positive and Gram negative bacteria. The following represents MIC susceptibility data for a few medically significant organisms.

  • Escherichia coli 1 μg/mL – 32 μg/mL
  • Haemophilus spp. 0.03 μg/mL – 2 μg/mL
  • Pseudomonas aeruginosa 4 μg/mL – 6.25 μg/mL

Synthesis

date = 1982 }}</ref>
doi = 10.1021/jm00324a056 }}</ref>

An interesting alternative synthesis of azlocillin involves activation of the substituted phenylglycine analogue 1 with 1,3-dimethyl-2-chloro-1-imidazolinium chloride (2) and then condensation with 6-APA.

References

References

  1. "Azlocillin sodium salt Susceptibility and Minimum Inhibitory and Concentration (MIC) Data". toku-e.com.
  2. (1982). "Azlocillin. Ein Neues Penicillin aus der Acylureidoreihe: Synthese und Chemische Eigenschaften". Eur. J. Med. Chem. - Chim. Ther..
  3. (November 1966). "Octamethylbiguanide perchlorate". Journal of Medicinal Chemistry.
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penicillins enantiopure-drugs imidazolidinones
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