Surf Wiki
Save to docs
general/cancer-treatments

From Surf Wiki (app.surf) — the open knowledge base

Autologous patient-specific tumor antigen response

FieldValue
nameAutologous patient-specific tumor antigen response
specialtyoncology

Autologous patient-specific tumor antigen response (apSTAR) technology is a new cancer treatment procedure being developed by IMULAN BioTherapeutics, LLC and Veterinary Cancer Therapeutics, LLC for comparative oncology.

Also known as laser-assisted immunotherapy, apSTAR is an experimental cancer treatment for solid tumors that uses an autologous vaccine-like approach to stimulate immune responses. Specifically, laser-assisted immunotherapy combines laser-induced in situ tumor devitalization with an immunoadjuvant for local immunostimulation. TOC

Principles of apSTAR

The two principles underlying apSTAR are: local destruction of tumor by means of a laser combined with a photo-absorbing dye and stimulated immune response due to the application of an immunoadjuvant, but also due to increases in antigen accessibility caused by the destruction of the tumor. Both elements of this protocol are crucial. Since this method independently triggers the immune response in each individual, it does not depend upon cross reactivity in the expression of tumor-specific antigen between hosts (as is required in conventional antibody immunotherapy and vaccination.)

Trials

Veterinary Cancer Therapeutics, LLC, a subsidiary of IMULAN BioTherapeutics, LLC, is in exploratory trials for canine osteosarcoma, canine melanoma, canine and feline fibrosarcoma, and several other forms of cancer.

References

References

  1. (June 2009). "Glycated chitosan as a new non-toxic immunological stimulant". Immunopharmacol Immunotoxicol.
  2. (2006). "Photoimmunotherapy for cancer treatment". J. Environ. Pathol. Toxicol. Oncol..
  3. (2005). "Enhancement of laser cancer treatment by a chitosan-derived immunoadjuvant". Photochem. Photobiol..
  4. (September 2003). "Laser immunotherapy: a novel treatment modality for metastatic tumors". Mol. Biotechnol..
  5. (August 2002). "Effect of different components of laser immunotherapy in treatment of metastatic tumors in rats". Cancer Res..
  6. (May 1999). "Long-term tumor resistance induced by laser photo-immunotherapy". Int. J. Cancer.
  7. (May 1997). "Laser-photosensitizer assisted immunotherapy: a novel modality for cancer treatment". Cancer Lett..
  8. "Archived copy".
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

cancer-treatments
Want to explore this topic further?

Ask Mako anything about Autologous patient-specific tumor antigen response — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report