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Arsenite methyltransferase

FieldValue
NameArsenite methyltransferase
EC_number2.1.1.137
CAS_number167140-41-2

Arsenite methyltransferase (, S-adenosyl-L-methionine:arsenic(III) methyltransferase, S-adenosyl-L-methionine:methylarsonite As-methyltransferase, methylarsonite methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:arsenite As-methyltransferase. This enzyme catalyses the following chemical reaction

: (1) S-adenosyl-L-methionine + arsenite \rightleftharpoons S-adenosyl-L-homocysteine + methylarsonate : (2) S-adenosyl-L-methionine + methylarsonite \rightleftharpoons S-adenosyl-L-homocysteine + dimethylarsinate

An enzyme of the biotransformation pathway that forms dimethylarsinate from inorganic arsenite and arsenate.

References

References

  1. (December 1999). "Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase". Chemical Research in Toxicology.
  2. (July 1999). "Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes". Toxicology and Applied Pharmacology.
  3. (September 1996). "Enzymatic methylation of arsenic compounds. III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic". Toxicology and Applied Pharmacology.
  4. (December 1995). "Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver". Chemical Research in Toxicology.
  5. (March 2002). "A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol". The Journal of Biological Chemistry.
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