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Arias-Stella reaction

Arias-Stella reaction
Micrograph showing Arias-Stella reaction in endometrium

Arias-Stella reaction, also Arias-Stella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue.

Arias-Stella reaction is due to progesterone primarily. Cytologically, it resembles a malignancy and, historically, it was misdiagnosed as endometrial cancer.

Significance

It is significant only because it can be misdiagnosed as a cancer. It may be seen in a completely normal pregnancy.

Diagnosis

It is characterized by nuclear enlargement and may also have any of the following: an irregular nuclear membrane, granular chromatin, centronuclear vacuolization, and pseudonuclear inclusions.

Five subtypes are recognized:

  1. Minimal atypia.
  2. Early secretory pattern.
  3. Secretory or hypersecretory pattern.
  4. Regenerative, proliferative or nonsecretory pattern.
  5. Monstrous cell pattern.

History

It was first described by Javier Arias Stella, a Peruvian pathologist, in 1954.

References

Bibliography

  • Textbook of Obstetrics by D.C.Dutta Page no. 180.

References

  1. (Jan 2002). "The Arias-Stella reaction: facts and fancies four decades after.". Adv Anat Pathol.
  2. (Aug 1954). "Atypical endometrial changes associated with the presence of chorionic tissue.". Arch Pathol.
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