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Arachnodactyly

Field	Value
name	Arachnodactyly
image	Aracnodactilia.jpg
caption	Bilateral arachnodactyly
synonyms	Achromachia
complications	None
onset	Birth
duration	Life-long
causes	Mutations in the fibrillin-2 gene, in chromosome 5q23, or the fibrillin-1 gene, at chromosome 15q21.1

Arachnodactyly ("spider fingers") is a medical condition that is characterized by fingers and toes that are abnormally long and slender, in comparison to the palm of the hand and arch of the foot. In some cases, the thumbs of an individual with the condition are pulled inwards towards the palm. This condition is present at birth.

Causes

This feature can occur on its own with no underlying health problems, or it can be associated with certain medical conditions, including Marfan syndrome, Ehlers–Danlos syndromes, Loeys–Dietz syndrome, and homocystinuria. It is also seen in congenital contractural arachnodactyly, which is caused by mutation in the gene encoding fibrillin-2 on chromosome 5q23.

Notable cases

It remains unconfirmed whether composer Sergei Rachmaninoff's abnormally large reach on a piano was a result of arachnodactyly due to Marfan syndrome, as the pianist exhibited no other signs of the disease.

References

Cleveland Clinic medical professional. (2024-10-30). "Arachnodactyly: Do You Have Spider Fingers?".
(April 1991). "Neonatal Marfan syndrome with congenital arachnodactyly, flexion contractures, and severe cardiac valve insufficiency". Journal of Medical Genetics.
(2003-06-27). "Hypermobility syndrome: Recognition and management for physiotherapists". Butterworth Heinemann.
(1993). "Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency".
(1994). "Congenital contractural arachnodactyly (Beals syndrome)". Journal of Medical Genetics.
(1972-04-01). ""New" Syndrome of Congenital Contractural Arachnodactyly, Originally Described by Marfan in 1896". Pediatrics.
(July 2023). "Forum - Search results for Rachmaninoff Marfan". Website of the Rachmaninoff Network.

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

congenital-disorders-of-musculoskeletal-system

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