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Anti-sp100 antibodies

Anti-sp100 antibodies are found in association with primary biliary cirrhosis. The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis. 20-30% of patients with primary biliary cirrhosis have sp100 Abs. The sera of these patients exhibit a characteristic "nuclear dots" pattern in indirect immunofluorescence (IIF) on Hep-2 cells.

Immunodominant regions of sp100

  • Antigenic region 1 - positions 296-311 - Sequence (I K K E K P F S N S K V E C Q A)
  • Antigenic region 2 - positions 332-351 - Sequence (E G S T D V D E P L E V F I S A P R S E) (Bolded areas represent the core epitope.)

References

References

  1. (1990). "Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis". J. Immunol..
  2. (1999). "Identification of major linear epitopes on the sp100 nuclear PBC autoantigen by the gene-fragment phage-display technology". Autoimmunity.
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