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Anti-actin antibodies

Anti-actin antibodies
Schematic representation of [[antibody

Anti-actin antibodies (AAA) are found at increased frequency in certain autoimmune diseases and may be of some diagnostic value.

In coeliac disease, anti-actin antibody levels correlate with the level of intestinal damage.

In autoimmune hepatitis, anti-actin antibody levels correlate with patterns of immune recognition, the pattern of recognition was specific to a small percentage of autoimmune hepatitis type 1 or cryptogenic hepatitis patients.

In gastric cancer anti-actin antibodies were elevated, along with other antibodies in severe disease with poor outcomes.

It has also been found as a paraneoplastic syndrome with myelodysplastic syndrome.

References

References

  1. (2005). "Significance of smooth muscle/anti-actin autoantibodies in celiac disease". Acta Gastroenterol. Latinoam..
  2. (2007). "IgA anti-actin antibodies ELISA in coeliac disease: A multicentre study". Digestive and Liver Disease.
  3. (2002). "Smooth muscle antibodies and type 1 autoimmune hepatitis". Autoimmunity.
  4. (2000). "Antibodies to soluble liver antigen: an additional marker in type 1 auto-immune hepatitis". J. Hepatol..
  5. (1998). "Autoantibodies in the serum of patients with gastric cancer: their prognostic importance". Hybridoma.
  6. (Oct 1995). "Paraneoplastic autoimmune phenomena in patients with myelodysplastic syndromes: response to immunosuppressive therapy". British Journal of Haematology.
  7. (1987). "Logan's Medical and Scientific Abbreviations". [[J. B. Lippincott Company]].
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