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Amyloid purpura

Field	Value
image	Purpura.jpg
caption	Purpura
specialty	dermatology

Amyloid purpura is a condition marked by bleeding under the skin (purpura) in some individuals with amyloidosis. Its cause is unknown, but coagulation defects caused by amyloid are thought to contribute.

Presentation

Amyloid purpura usually occurs above the nipple-line and is found in the webbing of the neck and in the face and eyelids.

Cause

The precise cause of amyloid purpura is unknown, but several mechanisms are thought to contribute. One may be a decrease in the level of circulating factor X, a clotting factor necessary for coagulation. The proposed mechanism for this decrease in factor X is that circulating amyloid fibrils bind and inactivate factor X. Another contributing factor may be enhanced fibrinolysis, the breakdown of clots. Subendothelial deposits of amyloid may weaken blood vessels and lead to the extravasation of blood. Amyloid deposits in the gastrointestinal tract and liver may also play a role in the development of amyloid purpura.

Epidemiology

Amyloid purpura affects a minority of individuals with amyloidosis. For example, purpura is present early in the disease in approximately 15% of patients with primary systemic amyloidosis.

References

(June 2007). "Image in clinical medicine. Amyloid purpura". N. Engl. J. Med..
(March 2000). "Clotting alterations in primary systemic amyloidosis". Haematologica.
{{eMedicine. med. 3363. Amyloidosis, Immunoglobulin-Related
(January 1995). "Primary systemic amyloidosis: clinical and laboratory features in 474 cases". Semin. Hematol..

Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

amyloidosis coagulopathies skin-conditions-resulting-from-errors-in-metabolism

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