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Amorpha-4,11-diene 12-monooxygenase

Class of enzymes

Field	Value
Name	Amorpha-4,11-diene 12-monooxygenase
EC_number	1.14.13.158

Amorpha-4,11-diene 12-monooxygenase (, CYP71AV1) is an enzyme with systematic name amorpha-4,11-diene,NADPH:oxygen oxidoreductase (12-hydroxylating). This enzyme catalyses the following chemical reaction

: amorpha-4,11-diene + 3 O2 + 3 NADPH + 3 H+ \rightleftharpoons artemisinate + 3 NADP+ + 4 H2O (overall reaction) :(1a) amorpha-4,11-diene + O2 + NADPH + H+ \rightleftharpoons artemisinic alcohol + NADP+ + H2O :(1b) artemisinic alcohol + O2 + NADPH + H+ \rightleftharpoons artemisinic aldehyde + NADP+ + 2 H2O :(1c) artemisinic aldehyde + O2 + NADPH + H+ \rightleftharpoons artemisinate + NADP+ + H2O

Amorpha-4,11-diene 12-monooxygenase is a heme-thiolate protein (P-450)

References

(February 2006). "Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin". FEBS Letters.

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ec-1.14.13

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