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Aminoaciduria

FieldValue
nameAminoaciduria
synonymsUrine amino acids
imageAmino acids in food and blood.png
captionShare of amino acid in various human diets and the resulting mix of amino acids in human blood serum. Glutamate and glutamine are the most frequent in food at over 10%, while alanine, glutamine, and glycine are the most common in blood.
complicationsSevere protein loss in the blood
risksLiver disease, malnutrition, kidney disease

Aminoaciduria occurs when the urine contains abnormally high amounts of amino acids. In the healthy kidney, the glomeruli filter all amino acids out of the blood, and the renal tubules then reabsorb over 95% of the filtered amino acids back into the blood.

In overflow aminoaciduria, abnormally high concentrations of amino acids in the blood plasma overwhelm the resorptive capacity of the renal tubules, resulting in high concentrations of amino acids in the urine. This may be caused by congenital disorders of amino acid metabolism, for example, phenylketonuria, or may be secondary to liver disease.

In renal aminoaciduria, the renal tubules are unable to reabsorb the filtered amino acids back into the blood, causing high concentrations of amino acids in the urine. This may be caused by a defect in the transport proteins in the renal tubule, for example, as occurs in Hartnup disease, or may be due to damage to the kidney tubule, for example, as occurs in Fanconi syndrome.

References

References

  1. "Aminoaciduria". NIH.
  2. (2013). "Mosby's Medical Dictionary". Mosby.
  3. (1984). "Examination of Kidney Function". Springer Netherlands.
  4. (2012). "Clinical biochemistry and metabolic medicine". Hodder Arnold.
  5. (2011). "Graff's textbook of routine urinalysis and body fluids". Wolters Kluwer/Lippincott Williams & Wilkins Health.
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