Amino acid transporter

Families

There are several families that function in amino acid transport, some of these include:

• TC# 2.A.3 - Amino Acid-Polyamine-Organocation (APC) Superfamily
• TC# 2.A.18 - Amino Acid/Auxin Permease (AAAP) Family
• TC# 2.A.23 - Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family
• TC# 2.A.26 - Branched Chain Amino Acid:Cation Symporter (LIVCS) Family
• TC# 2.A.42 - Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family
• TC# 2.A.78 - Branched Chain Amino Acid Exporter (LIV-E) Family
• TC# 2.A.95 - 6TMS Neutral Amino Acid Transporter (NAAT) Family
• TC# 2.A.118 - Basic Amino Acid Antiporter (ArcD) Family
• TC# 2.A.120 - Putative Amino Acid Permease (PAAP) Family

Solute carrier family examples

• (1) high affinity glutamate and neutral amino acid transporter
• (3) heavy subunits of heteromeric amino acid transporters
• (6) Bacterial Leucine Transporter (LeuT)
• (7) cationic amino acid transporter/glycoprotein-associated
• (15) proton oligopeptide cotransporter
• (17) vesicular glutamate transporter
• (18) vesicular amine transporter
• (25) some mitochondrial carriers
• (26) multifunctional anion exchanger
• (32) vesicular inhibitory amino acid transporter
• (36) proton-coupled amino acid transporter
• (38) System A & N, sodium-coupled neutral amino acid transporter

VIAAT===

Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles.

Human proteins containing this domain

SLC32A1; SLC36A1; SLC36A2; SLC36A3; SLC36A4; SLC38A1; SLC38A2; SLC38A3; SLC38A4; SLC38A5; SLC38A6.

References

References

1. (2004). "The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects". Pflügers Arch.
2. (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflügers Arch.
3. (2008). "A competitive inhibitor traps LeuT in an open-to-out conformation". Science.
4. (2004). "CATs and HATs: the SLC7 family of amino acid transporters". Pflügers Arch.
5. (2004). "The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology". Pflügers Arch.
6. (2004). "Organic anion transport is the primary function of the SLC17/type I phosphate transporter family". Pflügers Arch.
7. (2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflügers Arch.
8. Palmieri F. (2004). "The mitochondrial transporter family (SLC25): physiological and pathological implications". Pflügers Arch.
9. (2004). "The SLC26 gene family of multifunctional anion exchangers". Pflügers Arch.
10. Gasnier B. (2004). "The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids". Pflügers Arch.
11. (2004). "The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family". Pflügers Arch.
12. (2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family". Pflügers Arch.
13. [Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in {alpha}TC6 Cells, Mouse Clonal {alpha}-Cells, and {alpha}-Cells of Islets of Langerhans] Diabetes 52:2066-2074, 2003